Evidence suggests that
ACE inhibitors are low in side effects with few people
unable to tolerate them, including the elderly though doses may need
to be reduced. Less than 2% of patients in SOLVD (both treatment and
prevention trials)
had side effects severe enough to stop treatment.
Increased use of ACE inhibitors may lead to increased
incidence of renal failure in the elderly resulting from combination
therapy of ACE inhibitors with NSAIDS. This could have considerable resource
consequences.
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For further information about the AGREE Collaboration contact f.cluzeau@sghms.ac.uk