• Zusammenfassung von LL-Inhalt/-Empfehlungen

Clinical questions should address all the areas covered in the scope, and should avoid introducing new aspects not specified in the scope. They will, however, contain more detail than the scope, and should be seen as building on the fundamental framework of the guideline as laid out in the scope. The questions are usually drafted by the technical experts. They should then be refined and agreed by all GDG members through discussions. The different perspectives of GDG members ensure that the right questions are identified, thus enabling the literature search to be planned efficiently. Often, however, the main questions need refining once the evidence has been searched, and this may generate subquestions (see Chapter 6). Questions may also be submitted by stakeholders for the GDG to consider. The GDG should be explicit about the rationale it uses for selecting questions and should keep a detailed record of the proceedings leading to the decisions made.

• Example

At the start of each guideline development project, the guideline group break down the guideline remit into structured key questions. These questions form the starting point for the systematic literature review and it is therefore important that they are as clear and focused as possible, defining the target population, the intervention or exposure, the outcome, and form of comparison (e.g. with standard treatment or between alternative new therapies).

• Guideline introduction
• Search specification